Table 1: Antiviral therapy in HBeAg+ CHB
Interferon
5
Peg-IFN
7
Lamivudine
8
Adefovir
10
12 - 24 week
control
1 year
1 year
control
1 year
control
Loss of Serum DNA*(%)
37
17
32
44
16
21
0
Loss of HBeAg (%)
33
12
NA
17-32
6-11
24
11
HBeAg seroconversion (%)
18
32
16-18
4-6
12
6
Loss of HBsAg (%)
7.8
1.8
3
<1
0
0
0
Normalization of ALT (%)
23
NA
41-72
7-24
48
16
Histological improvement (%)
NA
NA
NA
49-56
23-25
53
25
* DNA assay
Interferon, Lamivudine - hybridization assay
Adefovir - PCR assay
Peg-IFN - < 10
5
cp/ml
difference in response between interferon and control.
18