Table 4: Recommendation for treatment in hepatitis B cirrhosis
(I) Compensated cirrhosis
  HBeAg   HBVDNA  
  +/-   < 104
  • Observe
  +/-   > 104
  • Lamivudine, Adefovir are first options, prefer Lam + Ade because of low likelihood of drug resistance
  • Peginterferon 2a, 2b, use cautiously
When to stop: Peginterferon a2a, a2b - 1/2 year - 1 year Lamivudine, Adefovir: Long term
         
(II) Decompensated cirrhosis
  HBeAg   HBVDNA  
  +/-   < 104
  • Observe
  • List for Liver transplant
  +/-   > 104
  • Lamivudine, Adefovir prefer Lam + Ade because of low likelihood of drug resistance
  • List for Liver transplant
When to stop: Lamivudine, Adefovir: Long term