Plate V
COMBINATION THERAPY FOR BIPOLAR DEPRESSION
Level of evidence
Lithium + valproate
2
1st line
Lithium or valproate + SSRI or bupropion
2
1st line
Olanzapine+ SSRI
2
1st line
Quetiapine + SSRI
3
2nd line
Risperidone + SSRI
3
2nd line
Lithium or valproate + venlafaxine
2
3rd line
Lithium + tricyclic
2
3rd line
Lithium + lamotrigine
3
3rd line
Lithium + carbamazepine
3
3rd line
Valproate + lamotrigine
3
3rd line