Table 4: Novel therapeutic modalities for SLE
Newer immunosuppressive agents
Mycophenolate mofetil
Tacrolimus
Leflumomide
Hormones
Dehydroepiandrosterone
B cell depletion
Fludarabine, rituximab, epratuzumab, belimumab
B cell tolerogen
LJP394-Riquent
Blockade of the co-stimulatory pathways
Abatacept
Neutralization of cytokines
IL-10, TNF, IL-6
Anti-complement
Anti-C5b (eculizumab)
Immunoablative cyclophosphamide
+
stem cell rescue